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KMID : 0854720120320030176
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 3 p.176 ~ p.182
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Sensitization to Inhalant Allergens and Its Association with Allergic Diseases in Preschool Children
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Choi Min-Hwan
Kwon Eun-Mi
Kim Hyo-Bin
Kim Chang-Keun
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Abstract
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Background: This study was conducted to investigate the recent prevalence of allergic diseases and the sensitization rate to inhalant allergens as well as their association in preschool children.
Methods: We performed a questionnaire survey and skin prick tests on 307 children aged 4 to 6 years from the northeast area of Seoul between April and July of 2009.
Results: The sensitization rate to inhalant allergens was 47.9%. The sensitization rate to house dust mites was the highest (41.7%) among tested allergens, followed by tree pollen (9.8%), animal dander (5.5%), weed pollen (2.0%) and Alternaria (1.6%), in decreasing order. The prevalence of wheezing during the past 12 months was 13.4%, that of allergic rhinitis was 27.6%, and that of atopic dermatitis was 21.7%. Atopy was associated with persistent symptoms of allergic rhinitis (adjusted odd ratio 2.00, 95% confidence interval 1.13∼3.53) and symptoms of allergic rhinitis during the past 12 months (adjusted odd ratio 1.89, 95% confidence interval 1.03∼3.44). Atopy was associated with everlasting (adjusted odd ratio 1.96, 95% confidence interval 1.07∼3.58) and symptoms of atopic dermatitis during the past 12 months (adjusted odd ratio 2.10, 95% confidence interval 1.09∼4.04). In addition, the increase in the number of sensitized inhalant allergens was associated with allergic rhinitis and atopic dermatitis.
Conclusion: Both sensitization to each inhalant allergen and the increase in the number of sensitized inhalant allergens may be risk factors for developing symptoms of allergic rhinitis and atopic dermatitis. (Korean J Asthma Allergy Clin Immunol 2012;32:176-182)
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KEYWORD
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Allergic rhinitis, Atopic dermatitis, Sensitization, Risk factors
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